Pharmacological Therapies NCLEX-PN practice questions
- of the exam
- 10–16% of the exam
- Client Needs category
- Physiological Integrity Client Needs category
- last updated
- October 2026 last updated
Pharmacological Therapies covers giving medications and monitoring clients on parenteral therapy. Items test routes and technique, dose and flow rate calculations, transfusion monitoring, reconciliation, and recognizing adverse reactions.
Updated October 2026
Pharmacological Therapies
5 free pharmacological therapies questions
Playable here, no account. Rationales expand in place.
Pharmacological Therapies · free set
1 of 5A practical nurse is preparing to instill prescribed ear drops into the right ear of a 2-year-old child admitted to a pediatric unit for otitis externa. Which action reflects correct technique for this age group?
Rationale
In children younger than 3 years, the ear canal is straighter and shorter; pulling the pinna downward and backward straightens the canal sufficiently to allow drops to reach the tympanic membrane. In adults and children 3 years and older, the pinna is pulled upward and backward. Option B: Ear drops should be warmed to room temperature by holding the bottle in the hand for a few minutes , not placed in hot water, which can overheat the solution, cause burns to the canal, or alter the medication's efficacy. Option C: Pulling the pinna upward and backward is the correct technique for adults and children 3 years of age or older; it does not adequately straighten the ear canal in a 2-year-old. Option D: After instillation, the child should remain lying with the treated ear facing upward for approximately 2 to 5 minutes to allow the drops to reach the canal; sitting upright allows gravity to drain the drops out immediately.
Answer: A
A practical nurse is monitoring a 45-year-old client who is 1 day postoperative from hip replacement surgery and is receiving a unit of packed red blood cells. Fifteen minutes after the transfusion begins, the client reports sudden low back pain and the practical nurse notes facial flushing and a temperature of 38.8°C (101.8°F). Which action should the practical nurse take first?
Rationale
Sudden low back pain, fever, and flushing occurring early during a blood transfusion are classic signs of an acute hemolytic transfusion reaction, a life-threatening emergency. The practical nurse must stop the transfusion immediately to halt further exposure to incompatible blood, then notify the RN without delay. Stopping the infusion is the essential first action. Option B: Administering acetaminophen does not address the underlying cause of the reaction and delays the critical intervention of stopping the transfusion. Option C: Waiting 30 minutes before rechecking vital signs is dangerous; a hemolytic transfusion reaction can progress rapidly and requires immediate intervention. Option D: Slowing but continuing the transfusion prolongs exposure to potentially incompatible blood and increases the risk of serious complications such as renal failure and cardiovascular collapse.
Answer: A
A practical nurse at a public health clinic is administering a tuberculin purified protein derivative (PPD) skin test to a 28-year-old client. Which technique indicates correct intradermal injection procedure?
Rationale
Intradermal injections are administered at a 5- to 15-degree angle with the bevel up into the ventral (inner) forearm. Correct placement produces a visible pale bleb of approximately 6–10 mm. No aspiration is performed and the site must not be massaged, as this could disperse the antigen and invalidate the test result. Option B: A 45-degree angle is used for subcutaneous injections, not intradermal; aspiration is not required for intradermal injections, and the outer upper arm is not the standard site for a PPD. Option C: The bevel must face up (not down) to ensure the injection remains within the dermis; 45 degrees is incorrect for an intradermal route, and firm pressure is contraindicated after a PPD. Option D: A 90-degree angle is used for intramuscular injections; the abdomen is not an appropriate site for a PPD test, and massaging after an intradermal injection disperses the antigen.
Answer: A
A 55-year-old male with esophageal cancer on a medical-oncology unit receives nutrition and medications via a gastrostomy tube (G-tube). The provider prescribes lisinopril 10 mg daily via G-tube; the medication is available as immediate-release tablets. Which technique by the practical nurse demonstrates correct G-tube medication administration?
Rationale
For an immediate-release tablet given via G-tube, the correct technique is to crush the tablet to a fine powder, dissolve it completely in 15–30 mL of water, administer the solution through the tube, and follow with a 15–30 mL water flush to ensure the full dose is delivered and the tube lumen is cleared. Water is the standard diluent because it avoids drug-nutrient interactions and pH-related instability. Option B: Medications must never be mixed directly into tube feeding formula; doing so risks drug-nutrient incompatibilities, altered bioavailability, and tube occlusion, and makes it impossible to confirm the full dose was actually received. Option C: Orange juice is acidic (pH ≈ 3.5) and can affect the stability or absorption of certain medications; water is the recommended and safest universal diluent for G-tube medication administration unless pharmacy specifies otherwise. Option D: A whole tablet cannot pass through the lumen of a G-tube and would cause an obstruction; all solid oral medications must be crushed or dissolved before enteral tube administration.
Answer: A
A practical nurse is preparing to administer amoxicillin 250 mg orally to a 6-year-old client in a pediatric clinic for a confirmed ear infection. Which actions demonstrate following the rights of medication administration? Select all that apply.
Rationale
The right patient requires verification using two identifiers; in an outpatient setting without an armband, the child's name and date of birth confirmed with the parent fulfill this requirement. The right drug and right dose require comparing the medication label against the prescription order before administration. The right route requires giving the medication by the oral route as prescribed and not substituting another route. Option A: The right time requires administering a medication at or within an acceptable window of the scheduled time; giving a dose 2 hours early violates this right and can disrupt therapeutic drug levels or lead to double-dosing. Option B: The right documentation requires recording in the medication administration record after administration, not before. Pre-documenting is a safety violation because it does not accurately reflect whether the medication was actually given. Option F: Medications must not be pre-poured, left unattended, or handed off to a non-licensed individual for delivery. The practical nurse retains responsibility for safe, witnessed administration of prescribed medications.
Answer: C, D, E
2026 test plan
What Pharmacological Therapies covers
A selection of the activities NCSBN lists for this category, in plain words.
- The rights of medication administration
- Oral, tube, injection and topical routes
- IV flow rates and piggyback medications
- Monitoring a blood transfusion
- Medication reconciliation and controlled substance counts
- Adverse reactions and critical lab values
How to answer these
When a client reacts, stop the drug first. Slowing it down, treating the symptom, or rechecking later all leave the client exposed.
Other NCLEX-PN categories
Coordinated Care
18–24% of the exam →
Safety and Infection Prevention and Control
10–16% of the exam →
Health Promotion and Maintenance
6–12% of the exam →
Psychosocial Integrity
9–15% of the exam →
Basic Care and Comfort
7–13% of the exam →
Reduction of Risk Potential
9–15% of the exam →
Physiological Adaptation
7–13% of the exam →
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